Graphics during model development

To compare and evaluate different kinds of models created during the model development process graphical and statistical methods should be applied. A good description of the model building process can be found elsewhere [14]. 

Graphs are useful in all phases of population PK/PD modeling. Before the analysis, the importance lies in data set checkout as well as exploratory analysis. During the analysis, graphical analysis is the mainstay in model diagnostics and guides model development. After the analysis, when the results need to be communicated, graphics can be used to transparently convey quite involved information. 

Sir James Dewar was born in Kincardine, Scotland, on September 20, 1842, the son of an innkeeper. He attended local schools until he was ten when he suffered a serious case of rheumatic fever lasting two years. During this period he built a violin, and music remained a lifelong interest of his. In 1858 he entered the University of Edinburgh. There he studied physics and chemistry. Dewar, in an early display of his dexterity, developed a mechanical model of Alexander Crum Brown s graphic notation for organic compounds. This was sent to Friedrich Kekule in Ghent who then invited Dewar to spend some time in his laboratory. 

As a tool for the ELMAS development a computer-model was created which used specifications of the functional interactions within the system based on Statecharts Statecharts are extended finite automata The model was combined with a graphical user interface for investigating the system behavior during running simulations [11]... 

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