Grapefruit juice serum concentrations

Kantola, T., Kivisto, K. T., Neuvonen, P. J., Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin add, Clin. Pharmacol. Ther. 1998, 63, 397—402. 

Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther 1999 66(2) 118-127. 

Grapefruit juice inhibits CYP3A4, and serum concentrations of atorvastatin, but not of pravastatin, increased after administration of double-strength grapefruit juice 200 ml tds for 2 days (109). 

Lilja, J.J., K.T. Kivisto, and P.J. Neuvonen. 1998. Grapefruit juice-simvastatin interaction Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin Pharmacol Ther 64 477. 

GRAPEFRUIT JUICE NILOTINIB (tyrosine kinase inhibitor) Grapefruit products t serum concentrations of nilotinib Due to effect of grapefruit juice as an inhibitor of CYP3A4 The dose of nilotinib should not exceed 400 mg once daily (a dose 1 to half the usual daily dose)... 

Administration of grapefruit juice (which inhibits both cytochrome P450 and P glycoprotein) to healthy volunteers resulted in an increased serum concentration ratio of losartan to its active metabolite E3174 (27). As both losartan and its metabolite contribute to the therapeutic effects, the absence of pharmacodynamic measurements in this study obviated conclusions about the clinical implications of this interaction. 

Grapefruit juice-simvastatin interaction effect on serum concentrations of simvastatin, simvastatin acid,... 

No. Chemical substances present in grapefruit juice inhibit cytochrome P450 isoenzymes involved in amlodipine metabolism. These substances decrease the first-pass metabolism of the drug and increase serum concentrations. 

---