Granules melt granulation technique

Bile Acids, Sterols, and Steryl Esters Many of these compounds have high melting points, making them unsuitable for melt applications. Exceptions are the salicylic acid-cholic acid system formed by a melt-granulation technique reported by Froemming and Vetter.f The system provided a sustained release in acid media (pH 1-3.5). 

McGinity, J.W. Koleng, J.J. Preparation and Evaluation of Rapid-Release Granules Using a Novel Hot-Melt Extrusion Technique, 1997, 2, 153. 

Glyceryl monostearate has also been used in a novel fluidized hot-melt granulation technique for the production of granules and tablets. 

Chaudhari PD. Melt granulation technique A review. Pharmainfo.net. (2006) 4 (1). 

As an alternative utilization concept for the cast iron, granulating is implemented. The main process of the granulating technique is given by the injection of the melt via a special nozzle into a water bath. 

Perissutti B, Rubessa F, Moneghini M, Voinovich D. Formulation design of carbama-zepine fast-release tablets prepared by melt granulation technique. Int J Pharm 2003 256 53 3. 

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