Granulation process another liquid

Extrinsic lubrication is provided via mechanisms that apply a lubricating substance, normally paraffin oil, to the tableting tool surface during processing. One method makes use of an oiled felt washer attached to the lower punch below the tip. This washer wipes the die cavity with each tablet ejection. To avoid having tablets stick to the punch faces, materials such as poly-tetrafiuorethylene or polyurethane have been applied to the faces. Another lubrication method sprays a thin layer of lubricant (either liquid or solid lubricant) onto the tool surfaces after one tablet is ejected and before the granulate of the next tablet enters the die cavity. 

Another piece of equipment that has been used to manufacture pellets by solution/suspension layering is the tangential spray or centrifugal granulator. An important parameter that needs to be established early in the process is quantity of starter seeds or cores charged into the machine that should, at the minimum, cover the nozzles during start-up otherwise, the sprayed liquid droplets will either be sprayed onto the wall of the product container or become entrained in the fluidization air. The latter could lead to clogging of the filters, which would then not only increase the pressure differential across the filters and compromise the batch but also may complicate equipment cleanup. In either case, the yield, and probably the quality of the pellets, will be reduced dramatically. As the size of the... 

We illustrate expansion and displacement of the domain using another example in process optimization, the formation of pellets by granulation in a high shear mixer, described by Vojnovic and coworkers (9). The object of this study was to map the effects of 3 factors, impeller speed (X,), amount of granulation liquid X, and the... 

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