Gram-negative microorganisms bacilli

Antibacterial activity of macrolides depends on the acidity of the medium. High activity is observed in neutral and basic media in comparison with acid. In particular, erythromycin is inactivated in the acidic medium of the stomach. Macrolides have a relatively broad spectrum of use, and they are active with respect to Gram-positive and Gram-negative microorganisms, achiomycetes, mycoplasma, spirochaeta, chlamydia. Bacteria Rickettsia, certain mycobacteria. Colon bacillus, blue-pus bacillus, shigella, salmonella, and so on. 

Kanamycin A is similar to streptomycin and neomycines and has a broad spectrum of antimicrobial action. It is active with respect to most Gram-positive as well as Gram-negative microorganisms (staphylococci, gastric bacilli, rabbit fever, Fridlender s bacillus, proteus, shigella, salmonella). 

Pedraza-Reyes, M. (1997). The bifunctional enzyme chitosanase-cellulase produced by the gram negative microorganism Myxobater.sp.AL-l is highly similar to Bacillus subtilis endo- glucanases. Arch Microbiol, 68, 321-327. 

Isoboldine was evaluated for its in vitro antimicrobial activity against a variety of microorganisms. The alkaloid was found to be inactive against Gram-positive and Gram-negative bacteria, as well as an acid-fast bacillus and a yeast. The oxoderivatives of aporphines were more... 

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