Gram-negative bacteria definition

Amphomycin is mainly active against gram-positive bacteria, with little or no activity against gram-negative bacteria or yeast . As its sodium salt, amphomycin has definite therapeutic effects against experimental Tr. gambiense and Tr. rhodesiense infections in mice and a curative value for fatal avian spirochetosis in chicks . It has successfully protected mice infected by intraperitoneal inoculation with 100 ISD oi Diplococcus pneumoniae ". It has been reported that the antibacterial activity of crystallomycin and amphomycin is lower in the presence of phosphates, but is completely restored after their removal (Table 1.7). 

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