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GPCR Dimerization

Various techniques have been routinely used to provide evidence for GPCR dimerization. However, each of these methodologies has its caveats, which should be considered for optimal experimental design and data interpretation. In fact, one definitive approach does currently not exist, and consequently multiple approaches [Pg.87]

The recent explosion of number of papers on GPCR dimerization is summarized in several reviews.81112 This chapter is devoted to briefly show importance of oligomerization of GPCRs, current state of knowledge in this area and potential applications. [Pg.454]

The future analysis of the binding of such ligands to heterodimers and homodimers, guided by structure-based modeling on GPCR dimers, will provide insights into the molecular determinants required for selective occupancy and/or activation of heterodimers. ... [Pg.409]

Key words Chemokine, Chemokine receptor, GPCR, Dimerization, BRET, FRET, Chemotaxis... [Pg.179]

In particular chemokine receptor heterodimers can have distinct pharmacological properties as compared to individual receptors (i.e., monomers and/or homodimers). Eventhough GPCR dimers are being identified and functionally characterized... [Pg.95]

See other pages where GPCR Dimerization is mentioned: [Pg.197]    [Pg.562]    [Pg.562]    [Pg.45]    [Pg.385]    [Pg.63]    [Pg.244]    [Pg.247]    [Pg.249]    [Pg.250]    [Pg.251]    [Pg.252]    [Pg.252]    [Pg.377]    [Pg.562]    [Pg.562]    [Pg.366]    [Pg.98]    [Pg.221]    [Pg.237]    [Pg.408]    [Pg.408]    [Pg.333]    [Pg.429]    [Pg.221]    [Pg.408]    [Pg.408]    [Pg.88]    [Pg.88]    [Pg.90]    [Pg.93]   


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