Gottlieb, Adam

Adam Gottlieb, A Concise Encyclopedia of Legal Herbs and Chemicals with Psychoactive Properties (Manhattan Beach, CA 20th Century Alchemist, 1973), p. 1. 

This bark is generally prepared by boiling so that psychoactive elements are leached out and starting material can be thrown away. Mental effects are fairly mild. Adam Gottlieb comments on yohimbe s propensity for producing sexual effects such as erections in males ... 

Kava-kava s mental action is caused by at least six resinous alpha pyrones kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin and dihydroyangonin, none of which is water soluble. As a result, they must be emulsified into water or coconut milk, says Adam Gottlieb,... 

A novel preparative synthesis of aporphines which should prove of appreciable utility in the future involves the cathodic cyclization of a l-(o-iodo-benzyl)isoquinoline methiodide salt. Gottlieb and Neumeyer have shown that electrolysis of l-(o-iodobenzyl)isoquinoline methiodide in dry acetonitrile containing tetraethylammonium bromide, and using a mercury cathode, furnished an 867o yield of the yellow didehydroaporphine which was reduced over Adams catalyst in methanolic hydrochloric acid to produce aporphine hydrochloride. The formation of didehydroaporphine proceeds via two one-electron reduction steps as shown below. 10,11-Dimethoxyaporphine was also prepared by this route. 

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