Gonadorelin acetate

Ovulation stimulants, synthetic clomiphene citrate gonadorelin acetate... 

Parenteral 500 mcg/mL in prefilled syringes for subcutaneous injection Gonadorelin acetate (Lutrepulse)... 

SYNS CYSTORELIN GONADORELIN ACETATE LUPROLITE ACETATE LUTEINIZING HORMONERELEASING FACTOR (SWINE), ACETATE (SALT) LUTREPULSE... 

Gonadorelin acetate Gonadorelin HCl Nafarelin acetate Leuprolide acetate Buserelin Goserelin acetate... 

Acetare (salt) hydrate, CjjH-jjN170iyxy H 20, gonadorelin acetate, Cystorelin Hypocrine, Lutrelef, Owrelin. As the diacetate tetrahydrate or a mixture of monoacetate and diacetate hydrates. 

Add-back estrogen replacement reduces the frequency and severity of these symptoms without apparently compromising the effectiveness of gonadorelin in women with endometriosis (19,27). In a randomized, multicenter, double-blind comparison of intranasal nafarelin twice daily and depot leuprolide acetate monthly for 6 months in 192 young women with endometriosis, nafarelin caused fewer hypoestrogenic symptoms, although the... 

Leuprolide acetate has been reported to cause normochromic normocytic anemia in patients with benign prostatic hyperplasia (37). The anemia is usually transient, and the hemoglobin returns to baseline 6 months after stopping androgen suppression. There is a single case report of more serious red cell aplasia in a patient receiving gonadorelin, with resolution after treatment was withdrawn (38). 

Injection site reactions are common with gonadorelin receptor agonists. In 119 women randomized to subcutaneous triptorelin a local reaction (redness, pain, or bruising) was present after 1 hour in 24% and persisted for 24 hours in 9.5% (41). In another study in 105 women randomized to leuprorelin acetate, moderate local reactions occurred in 24% and severe reactions in 1% (42). 

There were mild increases in serum triglyceride and cholesterol concentrations in 13 hirsute women treated with triptorelin and a triphasic oral contraceptive, in a randomized comparison of triptorelin with flutamide + cypro-terone acetate (85). Altered lipid profiles have not been described before in patients receiving gonadorelin agonists and oral contraceptives. 

The use of gonadorelin analogues is commonly associated with reduced bone mineral density. In 50 premenopausal women with uterine leiomyomas who received leuprolide acetate depot 3.75 mg every 28 days for 18 cycles with raloxifene 60 mg/day, there was a reduction in leiomyoma size with no significant change in bone mineral density or markers of bone metabolism [86],... 

U 69689) is a synthetic peptide analogue of gonadorelin (gonadotrophin-releasinghormone), a potent lh-rh RECEPTOR AGONIST with simiiar properties. It can be used in the treatment of gonadal steroid-dependent diseases and infertility in women. For further detail see gonadotrophinreleasing hormone, fertirelin acetate fertirelin. 

Musculoskeletal Gonadorelin has been used for the management of endometriosis in adolescents [8 ]. In this group the effect on bone mineral density can be minimized by using norethindrone acetate with or without estrogen at the same time. 

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