GOLPE

M Baroni, G Costantmo, G Craciam, D Riganelli, R Valigi, S dementi. Generating optimal linear PLS estimations (GOLPE) An advanced chemometnc tool for handling 3D-QSAR problems. Quant Struct-Act Relat 12 9-20, 1993. 

The variable selection methods have been also adopted for region selection in the area of 3D QSAR. For example, GOLPE [31] was developed with chemometric principles and q2-GRS [32] was developed based on independent CoMFA analyses of small areas of near-molecular space to address the issue of optimal region selection in CoMFA analysis. Both of these methods have been shown to improve the QSAR models compared to original CoMFA technique. 

Cruciani, G. and Watson, K.A. Comparative molecular field analysis using GRID force-field and GOLPE variable selection methods in a study of inhibitors of glycogen phosphorylase b. 

Baroni, M., Constantino, G., Cruciani, G., Riganelli, D., Valigli, R. and Clementi, S. (1993) Generating optimal linear pis estimations (GOLPE) An advanced chemometric tool for handling 3D-QSAR problems. Quantitative Stmcture-Activity Relationships, 12, 9-20. 

Ragno, R., Simeoni, S., Valente, S., Massa, S. and Mai, A. (2006) 3-D QSAR studies on histone deacetylase inhibitors. A GOLPE/GRID approach on different series of compounds. Journal of Chemical Information and Modeling 46,1420-1430. 

Sanz, F. 3D QSAR Methods on the Basis of Ligand-Receptor Complexes. Application of Combine and GRID/GOLPE Methodologies to a Series of CYP1A2 Inhibitors. /. Comput.-Aided Mol. Des. 2000, 13, 341-353. 

G., Riganelli, D, Valigli, R., Clementi, S. Generating Optimal Linear PLS Estimations (GOLPE) an Advanced Chemo-metric Tool for Handling 3D QSAR Problems. Quant. Struct.-Act. Relat. 

Cmciani, G., Watson, K. Comparative Molecular Field Analysis Using GRID Force Field and GOLPE Variable Selection Methods in a Study of Inhibitors of... 

AIRE (Air) Aire de animales (animal s air), golpe de aire (air hit), azote de aire de muerto (dead s air whip), mal de aire (air disease), aire de agua (water air), aire de basura (garbage air). Unspecific (29.32%) Assumed to be the action of some harmful external entity not always physic (air), which penetrates or sticks to some body part. Usually associated with skin, respiratory or muscle-skeletal problems. 

Cinnamomum zeylanicum (canela) Oenthera rosea (hierba del golpe)... 

Figure 2.1. Results of chemometric analysis by the GRID/GOLPE method for23 different WW domains, (a) Plot of the predicted vs. experimental NMR chemical shift perturbation (CSP). (b) Important contributions to recognition of tyrosine-containing peptides are shown. The WW domain (WWP3-1) is...

---