Golgi mannosidase II

Tulsiani, D.R.P., Broquist,H.P., and Touster, 0. (1985). Marked differences in the swainsonine inhibition of rat liver lysosomal Ot-D-mannosidase, rat liver Golgi mannosidase II, and jack bean Oi-D-mannosidase. Arch. Biochem. Biophys., 236, 427-434. 

A mouse model for HEMPAS disease was created by the inactivation of the Golgi mannosidase II gene and many of the characteristics of the human disease were reproduced [70]. The mice show anemia, splenomegaly, and immature erythrocytes or reticulocytes in the peripheral blood. Lectin blots and cell sorting... 

The enzyme activity termed mannosidase III (see discussion above) also has hallmarks of a Class 2 mannosidase. This enzyme has been found in rat liver microsomes [149 151] and in tissues from mice that have a disruption in the Golgi mannosidase II gene locus [70]. cDNAs or genes encoding the rat brain enzyme or a-mannosidase III have not been isolated, so the relationship to other Class 2 enzymes remains to be resolved. 

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