Gold GNPs synthesis

Fig. 4. Main methods for the preparation of gold GNPs. (A) Direct synthesis based on the reduction of a Au(III) salt and in situ protection of the nascent gold nanocluster with thiol-aimed glycoconjugates. (B) Ligand place exchange reactions based on the treatment of preformed gold nanoparticles with thiol-derivatized glycoconjugates. (C) Functionalization of gold nanoparticles by reaction between functional groups on gold surface and suitably derivatized carbohydrates. (See Color Plate 31.)...

Fig. 7. Gold GNPs by in situ protection with thiosemicarbazones carbohydrate derivatives and their UV-Vis spectra. (A) Synthesis of cellulose thiosemicarbazone (Cellulose-TSC). (B) Preparation and possible structure of a cellulose-conjugated gold nanoparticle. (C) UVAi is spectra and true-colour images of a GNP-free NMMO blank solution and GNPs/NMMO solutions a) Cellulose-free GNPs, b) Cel2oo-GNPs, and c) Celis-GNPs. Adapted from Ref 93. (See Color Plate 32.)...

In subsequent woik, aminooxy-functionalized gold nanoparticles were brought into reaction with glycosphingolipid (GSL) aldehydes to afford GNPs that reproduce the self-assembled microdomain model of multivalent GSLs present at the cell surface. The synthesis involves the selective transformation of the double bond in the ceramide... 

Hi) Non-covalent approaches to gold glyconanoparticles. Other protocols have been reported for the synthesis of GNPs in which the carbohydrates are non-covalently attached to the metal eluster. Saceharide-modified hyperbranched poly(ethylenimines) were used to elaborate eopper, silver, gold, and platinum nanoparticles. 12-a-C-Ribofuranosyl and ribopyranosyl dodecanoic acids were heated with silver nitrate in dilute alkaline solution to afford water-soluble 15 nm silver GNPs. ... 

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