Gold nanoparticles, functionalized

Finally, gold nanoparticles functionalized with thiols have emerged as a very interesting field of research. The gold particle is used as a core to which thiols are attached and the melting of the chains can give rise to LC-like behavior on the gold surface or to real mesophases. 

Bisaniline-cross-linked gold nanoparticles functionalized with thiophenylboronic acid... 

Gorin DA, Portnov SA, Inozemtseva OA et al (2008) Magnetic/gold nanoparticle functionalized biocompatible microcapsules with sensitivity to laser irradiation. Phys Chem Chem Phys 10 6899-6905... 

Taton et al. used gold nanoparticles functionalized with thiol-modified oligonucleotides to detect the presence of its complementary sequence hybridized on a transparent substrate (Fig. 13.9).16 In comparison to conventional fluorophore probes, this technique is three times more sensitive in discriminating an oligonucleotide sequence with a single basepair mismatch. In addition, signal amplification by reduction of silver ions on the nanoparticles drastically increased the sensitivity of... 

Recent work has been published on the use of SERS reporters for in vivo analysis. In 2008, Shuming Nie published work on the in vivo targeting of tumors in live mice [65]. The SERRS particles consisted of 60 nm gold nanoparticles functionalized with a Raman reporter dye molecule and then stabilized with thiolated polyethylene glycols (PEGs). Targeted SERS nanoparticles were prepared by having a mixed monolayer of thiolated PEG and a heterofunctional thiolated PEG with a carboxylic... 

Goodman, C. M., McCusker, C. D., Yilmaz, T., and Rotello, V. M. (2004). Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 15, 897-900. 

Gorin, D. A. Portnov, S. A. Inozemtseva, O. A. Luklinska, Z. Yashchenok, A. M. Pavlov, A. M. Skirtach, A. G. Moehwald, H. Sukhorukov, G. B. Magnetic/gold nanoparticle functionalized biocompatible microcapsules with sensitivity to laser irradiation. Phys. Chem. Chem. Phys. 2008,10, 6899-6905. 

An early example of this simple colorimetric technique based on this principle for the detection of low concentrations of heavy metal ions (Pb, Cd +, and Hg +) in aqueous solution has been reported by Hupp et al The ensemble in this case consists of gold nanoparticles functionalized with alkanethiol chains carrying carboxylate... 

The presence of Au-Tiopronin also played an important role for promoting crystal growth of the needle-shaped aragonite on the surface of the functionalized vaterite particles. The presence of Au-Tiopronin in the solution induced the second nucleation and growth of CaCOs crystals on the surface of the gold nanoparticle-functionalized vaterite particles. 

CT Gold nanoparticles functionalized with glutamic acid Targeting damaged bone tissue Zhang et al. (2010)... 

Figure 13.13 Plasmonics laser nanoablation of cancer cells (MDA-MB-468) labeled with 80nm gold nanoparticles functionalized with anti-EGFR antibodies, (a) Nanoparticles in red, imaged at 850nm wavelength through multiphoton luminescence, and cell membrane-impermeable dye (lOkDa FITC-...

Li, F. H. Wang, Z. H. Shan, C. S. Song, J. F. Han, D. X. Niu, L. (2009a). Preparation of gold nanoparticles/functionalized multiwalled carbon nanotube nanocomposites and its glucose biosensing application. Biosens, Bioelectron., 24,1765-1770. 

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