Gold -ferrocenyl complex

Other heterobimetallic aryl-phosphine-gold(I) complexes with different ferrocenyl derivatives, such as A-[2-A/,A/-(dimethylaminoethyl)-A-methyl-aminoethyl]-ferrocenyl (FcN,N), 2-nitroferrocenyl or ruthenocenyl, have also been reported. 

More recently, Echavarren and coworkers performed a detailed investigation of the enantioselective alkoxycyclization of functionalized enynes with gold (1) complexes in the presence of a variety of chiral ligands such as BEMAP, chiral 1,2-ferrocenyl phosphines and chiral 1,2-ferrocenyl-P N bidentate ligands. " Interestingly the authors... 

In parallel, Raubenheimer and coworkers developed new gold(I)-ferrocenyl complexes [11]. A series of cancer cell lines was tested with these, which includes HeLa cervix epithelioid carcinoma, CoLo 320 DM, Jurkat leukemia, and MCF-7 (breast cancer). The Jurkat cell lines were found to be the most responsive, while low sensitivity was observed for CoLo 320 DM. IC50 for HeLa and Jurkat were significant for complex 27 compared to cisplatin (Figure 7.10). 

The gold complex, generated in situ from bis(4-isocyanocyclohexyl)gold(I) tetrafluoroborate and (A)-A-methyl-,V-[2-(dialkylamino)ethyl]-l-[(5)-r,2-bis(diphenylphosphino)ferrocenyl]eth-ylamine, is an effective catalyst for the aldol reaction of various aldehydes with methyl iso-cyanoacetate to give the trans- and cw-4,5-dihydro-l,3-oxazoles. Depending on the aldehyde, the transjeis product ratio ranges from 84 16 to 100 0, and the ee of the main diastereomer is between 72 and 97%26. 

B. (2000) Gold and Silver Complexes with the Ferrocenyl Phosphine FcCH2PPh2 [Fc = (Tl5-C5H5)Fe(h5-C5H4)]. Inorganic Chemistry, 39(4), 680-687. 

Barranco, E.M., Gimeno, M.C., Laguna, A. and Villacampa, M.D. (2005) Gold and silver complexes with the ferrocenyl-pyrazolate ligand FcCH2pz. Inorganica Chimica Acta, 358 (14), 4177 182. 

CH2py) = l-methyl-3-(2-pyridinylmethyl)-imidazolium] (Figure 2.57a) whose luminescent behavior has been described [307], 2-bis(trimethylsilyl)methylpyridyl [308] or 2-(dimethylaminomethyl)ferrocenyl [309] complexes. In the dinuclear derivative with the 4,5-dihydro-4,4-dimethyl-l,3-oxazol-2-yl)thien-3-yl ligand (Figure 2.57b) the gold-gold distance is 2.8450(6) A [310]. 

Some —H - -Au contacts have also been described in gold complexes with ferrocenyl derivatives as ligands, such as those included in Table 5.2 containing... 

Ferrocenyl ligands, via zinc reagents, 9, 120 Ferrocenylmethyl phosphonium salts, with gold(I), 2, 274 Ferrocenylmonophosphine, in styrene asymmetric hydrosilylation, 10, 817 Ferrocenyl oxazolines, synthesis, 6, 202 Ferrocenylphosphines with chromium carbonyls, 5, 219 in 1,3-diene asymmetric hydrosilylation, 10, 824-826 preparation, 6, 197 various complexes, 6, 201 Ferrocenylselenolates, preparation, 6, 188 Ferrocenyl-substituted anthracenes, preparation, 6, 189 Ferrocenyl terpyridyl compounds, phenyl-spaced, preparation 6, 188 Ferrocifens... 

The use of ferrocenyl derivatives has also led to the synthesis of other trinuclear organogold(I) complexes that usually contain the fragment C-Au-P. Some of them contain l,l/-bis(diphenylphosphino)ferrocene (dppf) bridging two gold(I) atoms and a variety of aryl groups (see Table XV). They have been prepared by treatment of the trinuclear chloro derivative [(ClAu)2(dppf)] with two equivalents of the corresponding aryllithium [Eq. (39)] and their photophysical and electrochemical properties have been studied.126... 

It is surprising that transition metal complexes containing ferrocenyl thio-late ligands (FcS) have not been studied in detail so far. The only examples are gold complexes such as (Fc-S)Au(PPh3) [86], [(FcS)Au2(PPh3)2](BF4) [86, 183], [(Ph3PAu-S)fc-S-]2 (Scheme 5-18) [90], and [(FcS)Au(nBu)2]3 [86],... 

Hurst, S.K., Humphrey, M.G., Morrall, J.P., Cifuentes, M.P., Samoc, M., Luther-Davies, B., Heath, G.A., WilUs, A.C. Organometallic complexes for nonUnear optics. Part 31. Cubic hyper-polarizabilities of ferrocenyl-Unked gold and ruthenium complexes. J. Organomet. Chem 670, 56-65 (2003)... 

Hayashi and Ito have shown that the reaction of methyl isocyanoacetate (MeOCOCH2NC) with aldehydes is catalyzed by gold [339, 408, 752, 1060] or silver [951] complexes. In the presence of ferrocenyl bisphosphines 3.41 (R = CH2CH2NMe2 or CH2CH2N(CH2)5) the reaction is diastereo- and enantio-selective, and provides trans oxazolines 6.131. These oxazolines are precursors of... 

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