Glyoxylate formation from isocitrate

The glyoxylate cycle (Figure 9.13) consists of five reactions. The first two reactions (the synthesis of citrate and isocitrate) are familiar ones, because they also occur in the citric acid cycle. However, the formation of citrate from... 

In the tricarboxylic acid cycle acetyl CoA is degraded to COg and reduced pyridine nucleotides (NADH and NADPH, D 16.2). In addition it supplies intermediates for the biosynthesis of the amino acids L-glutamic acid (D 17) and L-aspartic acid (D 16). The carbon chains withdrawn from the cycle by amino acid biosynthesis are replaced by degradation of isocitric acid to succinic acid and glyoxylic acid and the formation of malic acid from the latter. The tri-carboxyhc acid cycle short-circuited by these reactions is known as the glyo-xyhc acid cycle. 

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