Glycosylation reactions experimental studies

More interesting are the substitution reactions on the triazole ring where a characteristically different course can be expected from that of analogous reactions in the purine series. These reactions were studied in more detail only in connection with the preparation of the glycosyl derivatives, and the experimental material does not permit the drawing of general conclusions. 

Experimental studies have shown that Leucinostatin A may be one of the several potentially toxic peptides produced by Acremonium sp. that contribute to the defense of the host. The host plant is relatively immune to Leucinostatin A, because it has an enzyme which transfers two glycosyl residues to leucinostatin A, thus reducing the peptide s bioactivity. From these results it can also be concluded that glucosylation reactions may play a general role in plant defenses, especially against toxin-mediated disease development [120]. 

Experimental and/or theoretical studies to assess the role of H-bonding and proton transfer at or near the TS of glycosylation reactions. This not only requires reliable models of TSs, but also good computational methods for H-bonding. 

Several carbohydrate applications have been included in a review of micro-wave-assisted organic reactions, and a survey of chemical reagents in photo-aflinity labelling included the role of various base-labelled azido- and thio-nucleosides, sugar azide derivatives and p-benzoylbenzoate esters of nucleosides. A further review intitled Reverse Anomeric Effect Fact or Fiction refers to early evidence based on studies of glycosyl pyridinium and imidazolium salts. It concludes that its origin as an electronic effect is not supported by theory or experimental results. ... 

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