Glycosylation Effect

T. A. Gerken, Kinetic modeling confirms the biosynthesis of mucin core 1 (/i-Gal (1 -3)x-Gal YAc-O-Ser/Thr) O-glycan structures are modulated by neighboring glycosylation effects, Biochemistry, 43 (2004) 4137—4142. 

In addition, the fulvestrant could be glycosylated effectively at its 17-OH position with pivaloylated glycosyl trichloroacetimidates, which suppressed the competing transacylation side reaction and led to improved yields of the desired glycosides (Scheme 3.48d) [503]. In this synthesis, the inverse procedure (i.e. addition of a trichloroacetimidate donor to a mixture of an acceptor and a promoter) was found to be superior for glycosylations. Very recently, a stepwise synthesis of branched... 

A. S. Shashkov, A. I. Usov, Y. A. Knirel, B. A. Dmitriev, and N. K. Kochetkov, Determination of absolute and anomeric configurations of monosaccharides in oligo- and poly-saccharides by glycosylation effects in 13C-NMR spectra, Bioorg. Khim., 7 (1981) 1364-1371. 

Glycosylation effects ( =a-shifts) refer to the change in shift of the O-substituted carbon signals on the transformation OH—> 0 Gly. 3-Glycosylation effects ( =3shifts) are the change in shift of the resonances of the adjacent 3-carbon atoms. 

Kedzierski, W, Bok, D., and Travis, G.H. Transgenic analysis of rds/peripherin N-glycosylation effect on dimerization, interaction with roml, and rescue of the rds null phenotype. /. Neurochem. 72 430-438,1999. 

Inhibition of Protein Glycosylation Effects of Nucleotide Deoxysugars on the Formation of Glycosylated Lipid Intermediates , Archives of Biochemistry and Biophysics, 206, 65-71... 

In the last mentioned paper it was shown that the n.m.r. spectra for this type of trisaccharide can, in most cases, be calculated by application of the glycosylation effect to the respective disaccharide spectra. ... 

---