Glycosylation, chemical solid-phase oligosaccharide

High selectivity and substrate specificity of glycosyl transferases make them valuable catalysts for special linkages in polymer-supported synthesis. There is, however, still a rather limited set of enzymes available to date, and the need to synthesize a variety of natural and non-natural oligosaccharides prevails. Particularly with regard to combinatorial approaches, chemical solid-phase oligosaccharide synthesis promises to meet the demands most effectively. 

Table 3. Major linkers used in two-phase (solid state) oligosaccharide synthesis showing chemical structure of the linker, glycosylating agent, and removal methods used. 

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