Glycosyl glycosylations using

Glycosylation Using Glycosyl Fluorides as Glycosyl Donors 36... 

General Procedure for One-Pot Glycosylation Using Glycosyl Iodides 90 References 90... 

Glycosylation Using Clycosyl Fluorides as Clycosyl Donors... 

In 1980, Gross and coworkers first applied this concept to a direct dehydrative glycosylation using tris(dimethylamino)phosphine and carbon tetrachloride [99]. 

Scheme 5.70 Sequential, one-pot glycosylation using 1,2-anhydro sugars.

Kunz et al. demonstrated the glycosylation using N-glycosyl triazoles as glycosyl donors [238]. These glycosyl donors were prepared from the corresponding glycosyl... 

Table 5.2 Glycosylation using different glycosyl sulfonylcarbamates [236]...

Glycosylation of MPEG-DOX-OH with 76 was achieved in 95% yield. After deacetylation using DBU in methanol, glycosylation using disaccharide donor 78 was performed and resin-linked trisaccharide was obtained in 85% yield. 

Common Anomeric Groups, Common Activators Both conformational and electronic factors have been exploited to obtain selectivity in one-pot glycosylations using common anomeric groups and activators. Selectivity results from differences in the stability of oxonium ion intermediate between the two prospective glycosyl donors. 

Glycosylation of the free hydroxyl-functions of the polymer-bound peptides 62-65 was achieved by the trichloroacetimidate glycosylation procedure.13 After glycosylation using the first donor, the perbenzoyl-D-galactosyltrichloroacetimidate... 

In viruses where the genome is contained within a single nucleic acid molecule, translation produces a large multifunctional protein, a polyprotein, which is then cleaved enzymatically to produce a number of distinct proteins. In viruses where the genome is distributed over a number of molecules, several mRNAs are produced, each being translated into separate proteins. After translation they may be glycosylated using host enzymes. 

For example, glycosylation using 2,3,4,6-tetra-O-acetylglucopyranosyl bromide provided the (3-anomer as the major product due to the neighboring group assistance (Scheme 4.10). However, the preferred a-anomer can be separated from the less active (3-anomer, and assayed individually (Table 4.3). 

Chemical glycosylation used to be a classical method of choice however, in the last 10-20 years a plethora of enzymatic methods for the synthesis [5, 6] and... 

Enzymatic mannosylation of the alkaloids by a-mannosidase from Canavalia ensiformis (Jack beans) was accomplished via two different strategies - transglycosylation using p-nitrophenyl-a-D-mannopyranoside or reversed glycosylation using a high concentration of mannose [46] (Fig. 10). 

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