Glycosignaling domain

Vyas AA, Blixt O, Paulson JC, Schnaar RL. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro. J. Biol. Chem. 2005 280 16305-16310. Iwabuchi K, Zhang Y, Handa K, Withers DA, Sinay P, Hako-mori S. Reconstitution of membranes simulating glycosignaling domain and their susceptibility to lyso-GM3. J. Biol. Chem. 2000 275 15174-15181. 

Cell Adhesion Coupled with Signal Transduction 773 Table 2. GSLs and transducers associated with glycosignaling domain (GSD) of tumor cell lines. 

Cell Adhesion Coupled ivith Signal Transduction Initiated by GSL Microdomain Concept of Glycosignaling Domain (GSD)... 

Tabk 3. Differences between GSL microdomain (glycosignaling domain) and caveolae in B16 melanoma cells, in terms of chemical composition and function. 

Simons K, van Meer G Lipid sorting in epitheUal cells. Biochemistry 1988 27 6197-6202. Iwabuchi K, Zhang Y, Handa K, Hakomori S Lyso-GM3 specifically disrupts structure and function of GM3-enriched glycosignaling domain in B16 melanoma cells [Abstract]. FASEB J. 1999 in press. 

---