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Glycoproteins sugar side-chains

Stability Sugar side chains can potentially stabilize a glycoprotein in a number of ways, including enhancing its solubility, shielding hydrophobic patches on its surface, protection from proteolysis and by direct participation in intrachain stabilizing interactions... [Pg.31]

J.C. Paulson. 1989. Glycoproteins What are the sugar side chains for Trends Biochem. Sci. 14 272-276. (PubMed) R.J. Woods. 1995. Three-dimensional structures of oligosaccharides Curr. Opin. Struct. Biol. 5 591-598. (PubMed) Books... [Pg.485]

Kobata, A. 1992. Structure and function of the sugar side-chains of glycoproteins. Eur ] Bio-chem 209, 483-501. [Pg.50]

Paulson, J. C.,1989. Glycoproteins What are the sugar side chains for Trends Biochem. Sd. 14 272-276. [Pg.316]

FIGURE 8.18 Dolichol phosphate is an initiation point for the synthesis of carbohydrate polymers in animals. The analogous alcohol in bacterial systems, undecaprenol, also known as bactoprenol, consists of 11 isoprene units. Undecaprenyl phosphate delivers sugars from the cytoplasm for the synthesis of cell wall components such as peptidoglycans, lipopolysaccharides, and glycoproteins. Polyprenyl compounds also serve as the side chains of vitamin K, the ubiquinones, plastoquinones, and tocopherols (such as vitamin E). [Pg.253]

The sensitivity to periodate of Ser and Thr is thousands of times greater than that of the better known periodate oxidation of 1,2-cis-diols, for example in the sugars of glycoproteins.19 This means that the concentration of reagent can be kept very low, in only small excess over the l-amino-2-alcohol, and the reaction time kept short (3 to 10 min). It is, thus, usually possible to avoid oxidative attack of the side chains of Met, Trp, and His, but some risk of... [Pg.83]

Usually, only one or a small number of side chains of a protein is modified. However, glycoproteins may contain many different attached sugar molecules. An example is the glucoamylase shown in Fig. 2-29. In several proteins involved in blood clotting (Fig. 12-17), as many as 10 glutamic acid side chains are carboxylated (Eq. 2-20). [Pg.80]

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Glycoproteins sugars

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