Glycolipids chemical synthesis

For this purpose, Ag zeolite and Ag, developed by Garegg25 and Paulsen,26 respectively, have been widely employed (Scheme 7.6). Reactions using these activators have found practical use in synthetic studies on glycoprotein glycans and glycolipids. For instance, Paulsen reported the chemical synthesis of the core pentasaccharide structure 6 common to all types of Asn-linked glycans, using the Ag... 

Chemical Synthesis and Modification of Oligosaccharides, Polysaccharides, Glycoproteins, Enzymes, and Glycolipids... 

Purification of 26 from the enzyme and excess sugar building block by gel-filtration chromatography was facilitated by the presence of the poly(acryla-mide) support. Subsequent treatment of 26 with leech ceramide glycanase in the presence of an excess of ceramide as an acceptor generated the transglyco-sidated product GM3 27 in 61% yield. Thus, this polymer-supported enzyme approach afforded the glycolipid GM3 in 56% yield from the readily available precursor/monomer 24, a remarkable improvement in both the ease of synthesis and overall yield when compared to that of chemical synthesis (19). 

Enzyme Catalysis, Chemical Strategies for Glycan Biosynthesis in Mammals Glycosyltransferases, Chemistry of Glycolipids, Synthesis of Glycopeptides and Glycoproteins, Synthesis of... 

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