Glycogen metabolism Glucose-6-phosphate increase

The influence of the adrenal hormones and of insulin on the metabolism of pyruvate and glucose by rat diaphragm muscle has been studied by Villee et al. (1952), who proposed (1) that the adrenal hormones inhibit hexokinase, as postulated by Colowick et al. (1947) (2) that the absence of the adrenals inhibited the conversion of glucose-6-phosphate to glycogen and (3) that some step in the condensation of pyruvate with oxaloacetate was accelerated by insulin and retarded by the adrenal hormones. The latter point was based in part on the observation that, in muscle from adrenalectomized rats, lactic acid production was decreased and the oxidation of pyruvate to CO2 was increased. All these suggestions... 

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