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Glycoform profile

There are several sources of commercially available OVA, and CZE can be used to distinguish their glycoform profiles [ 146]. Two batches of turkey egg ovalbumin (tOVA) showed qualitatively similar glycoform profiles with some differences in the levels of a number of glycoforms (Figure 22.23a and b). On the other hand, the glycoform profile of chicken egg ovalbumin (cOVA) (Figure 22.23c)... [Pg.673]

The biophysical properties of two commercially available rhEPO-a products, Epogen and Eprex, both of which are produced under similar conditions by different manufacturers, were studied [169]. Among many techniques used in this study, the analysis by CZE showed that the products had similar glycoform profiles in terms of isoform type and distribution, an indication that the products had similar sialic acid contents. [Pg.676]

FIGURE 14 Effect of dissolved oxygen on the glycoform profile of IgG. [Pg.129]

Figure 3. Dionex HPAEC profiles following 45 minute digestion of 1.25% PGA by 0.1 RGU each of 3 different glycoforms of F. Moniliforme EPGs. Figure 3. Dionex HPAEC profiles following 45 minute digestion of 1.25% PGA by 0.1 RGU each of 3 different glycoforms of F. Moniliforme EPGs.
Figure 6. Dionex HPAEC profiles following 48 hour digestion of 1.25% PGA by 0.1 RGU each of 4 different EPGs inhibited by cv cannelino cultured cell PGIP. A and B) F. moniliforme EPG glycoforms, C) deglycosylated S. cerevicae expiressed EPG, D) S. cerevicae expressed EPG. Figure 6. Dionex HPAEC profiles following 48 hour digestion of 1.25% PGA by 0.1 RGU each of 4 different EPGs inhibited by cv cannelino cultured cell PGIP. A and B) F. moniliforme EPG glycoforms, C) deglycosylated S. cerevicae expiressed EPG, D) S. cerevicae expressed EPG.
Monosaccharide Glycoform Glycosylation Site Map Composition Profile... [Pg.1875]

Triple-quadrapole, ion-trap, and Q-TOF instruments were compared in MS and MS-MS with product-ion, neutral-loss, and precursor-ion analysis modes for the profiling of the Asn -A-glycan of the a-unit of ovine luteinizing hormone [86]. More than 20 glycoforms were detected and identified. The Q-TOF allowed the lowest sample consumption, but all three instruments contributed to the profiling study. [Pg.537]

It was shown that the chromatography method was suitable to separate recombinant EPO from amounts of human serum albumin commonly present as a stabilizer in various pharmaceutical preparations. In addition, it was possible to obtain different elution profiles for EPO products with variations in the glycoforms. Fluorescence detection was applied for quantification and showed linear signals over the range of 10-200-pg/mL EPO. [Pg.603]


See other pages where Glycoform profile is mentioned: [Pg.137]    [Pg.1876]    [Pg.1876]    [Pg.1876]    [Pg.2116]    [Pg.230]    [Pg.89]    [Pg.25]    [Pg.664]    [Pg.665]    [Pg.675]    [Pg.676]    [Pg.677]    [Pg.22]    [Pg.1011]    [Pg.239]    [Pg.250]    [Pg.250]    [Pg.158]    [Pg.137]    [Pg.1876]    [Pg.1876]    [Pg.1876]    [Pg.2116]    [Pg.230]    [Pg.89]    [Pg.25]    [Pg.664]    [Pg.665]    [Pg.675]    [Pg.676]    [Pg.677]    [Pg.22]    [Pg.1011]    [Pg.239]    [Pg.250]    [Pg.250]    [Pg.158]    [Pg.277]    [Pg.278]    [Pg.188]    [Pg.242]    [Pg.242]    [Pg.269]    [Pg.285]    [Pg.225]    [Pg.247]    [Pg.597]    [Pg.1873]    [Pg.2117]    [Pg.91]    [Pg.92]    [Pg.94]    [Pg.126]    [Pg.176]    [Pg.801]    [Pg.801]    [Pg.131]    [Pg.161]   
See also in sourсe #XX -- [ Pg.1876 ]

See also in sourсe #XX -- [ Pg.25 ]




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Glycoforms

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