Glycine synthesis and

These two selectors terminated with a glycine were then prepared on a larger scale, their carboxyl groups reacted with 3-aminopropyltriethoxysilane, and the conjugate immobilized onto silica. Each CSP was packed into columns and used for the separation of racemic (l-naphthyl)leucine ester 17. Separation factors of 6.9 and 8.0 were determined for the columns with DNB-ala-gly and DNB-leu-gly selector respectively. These were somewhat lower than those found for similar CSPs using the parallel synthesis and attached through a different tether [87]. 

The imines of ( )-(l/ ,2/ ,5/ )-2-hydroxy-3-pinanone and glycine, alanine and norvaline methyl esters were highly successful as Michael donors in the asymmetric synthesis of 2,3-di-substituted glutamates. The chiral azaallyl anions derived from these imines by deprotonation with lithium diisopropylamide in THF at — 80 "C undergo addition to various ,/ -unsaturated esters with modest to high diastereoselectivities210,394. 

Creatinine is formed in muscle from creatine phosphate by irreversible, nonenzymatic dehydration and loss of phosphate (Figure 31-6). The 24-hour urinary excretion of creatinine is proportionate to muscle mass. Glycine, arginine, and methionine all participate in creatine biosynthesis. Synthesis of creatine is completed by methylation of guanidoacetate by S-adenosylmethio-nine (Figure 31-6). 

Verleysdonk, S, Martin, H, Willker, W, Leibfritz, D and Hamprecht, B (1999) Rapid uptake and degradation of glycine by astroglial cells in culture synthesis and release of serine and lactate. Glia 27 239-248. 

GLYCINE AS A CENTRAL NEUROTRANSMITTER GLYCINE SYNTHESIS, UPTAKE AND DEGRADATION 298... 

The underlying biochemical defect is a failure of mitochondrial uptake of ornithine. This results in a failure of citrulline synthesis and a consequent hyperammonemia. Urinary orotic acid is high, presumably because of underutilization of carbamyl phosphate. In contrast, excretion of creatine is low, reflecting the inhibition of glycine trans-amidinase by excessive levels of ornithine. 

Ashton, W.T., Dong, H., Sisco, R.M., Doss, G.A., Leiting, B., Patel, R.A., Wu, J.K., Marsilio, F., Thornberry, N.A. and Weber, A.E. (2004) Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl) glycine pyrrolidides and fhiazolidides as dipeptidyl peptidase IV inhibitors. Bioorganic at Medicinal Chemistry Letters, 14, 859-863. 

The amino acids glycine, aspartate, and glutamine are used in purine synthesis. 

They are required for the synthesis of conditionally essential amino acids, e.g. arginine, glycine, cysteine and glutamine. 

Researchers at the University of Graz, in collaboration with scientists from DSM, have developed an elegant and novel approach to the synthesis of P-amino alcohols using two different enzymes in one pot (Scheme 2.35). For example, a threonine aldolase-catalyzed reaction was initially used, under reversible conditions, to prepare L-70 from glycine 69 and benzaldehyde 68. L-70 was then converted to (R)-71 by an irreversible decarboxylation catalyzed by L-tyrosine decarboxylase. In a second example, D/L-syn-70 was converted to (R)-71 using the two enzymes shown combined with a D-threonine aldolase in greater than 99% e. e. and 67% yield ]37, 38]. 

Gershoff, S. N., and Earagalla, E. F. (1959). Endogenous oxalate synthesis and glycine, serine, deoxypyridoxine interrelationships in vitamin B6-deficient rats. /. Biol. Chem. 234, 2391-2393. 

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