Glycine NMDA receptors

The synthesis of Merck s glycine NMDA receptor or antagonist L-701,324 is illustrative, it can be prepared in one step by use of this procedure the reported synthetic procedure comprises several reaction steps. 

Christensen, D., Guilbaud, G., Kayser, V. The effect of the glycine/NMDA receptor antagonist, (+)-HA-966, on morphine dependence in neuropathic rats, Neuropharmacology, 2000, 39, 1589-1595. 

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Patankar, S.J. and Jurs, P.C. (2002) Prediction of glycine/NMDA receptor antagonist inhibition from molecular structure. J. Chem. Inf. Comput. Sci., 42, 1053-1068. 

Cai SX (2006) Glycine/NMDA receptor antagonists as potential CNS therapeutic agents ACEA-1021 and related compounds. Curr Top Med Chem 6 651-662... 

Dansysz, W., Parsons, C.G., 1998. Glycine, NMDA receptors — physiological significance and possible therapeutic applications. Pharmacological Reviews 50, 597-664. 

Lbscher, W., Wlaz, P., Rundfeldt, C Baran, H., Honack, D., 1994. Anticonvulsant effects of the glycine/NMDA receptor ligands d-cycloserine and d-serine but not R(-l-)-HA-966 in amygdala-kindled rats. Br. J. Pharmacol. 112, 97-106. 

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Aryl-4-hydroxyquinolin-2(li-f)-ones, which are of pharmaceutical interest, were readily obtained in a one-pot procedure by formal amidation of malonic ester derivatives with an aniline then cyclization of the intermediate malondianilides (Scheme 10.103) [200]. The synthesis of Merck s glycine NMDA receptor or antagonist l-701,324 is illustrative. It can be prepared in one step by use of this procedure whereas the previously reported synthetic procedure comprises several reaction steps. 

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