Glycine N-methyltransferase

Fig. 2.2.1 Outline of homocysteine metabolism in man. BMT Betaine methyltransferase, cblC cobalamin defect type C, cblD cobalamin defect type D, GNMT def glycine N-methyltransferase deficiency, MAT methionine adenosyl transferase, MeCbl methylcobalamin, Met Synth methionine synthase, MTHFR methylenetetrahydrofolate reductase, SAH Hyd dc/S-adenosylhomocys-...

Yeo E, Wagner C (1994) Tissue binding of glycine N-methyltransferase, a major folate-binding protein of liver. Proc Natl Acad Sci U S A 91 210-214... 

Glycine N-methyltransferase 591,593s Glycine reductase 824 Glycocalyx 6... 

A third group of OMTs are the protein carboxyl MTs, whose molecular mass is approximately 27 kDa 43 These proteins are found in almost all organisms, and they serve to repair damaged proteins. In plants, they have been shown to be important during stress and in seed viability.14. Their sequences are related to the animal glycine N-methyltransferases (NMTs) and die RNA/DNA MTs. Furthermore, the plant protein carboxyl MTs share no similarity to the other plant MTs involved in specialized metabolism. The enzyme that methylates a carboxyl functionality of Mg-protoporphyrin IX to produce a methylester constitutes a fourth type of plant OMT. This chloroplastic protein, whose mature form has a molecular mass of 31 kDa, is related to MTs with similar functions from photosynthetic bacteria, but is not closely related to any other plant OMTs.6... 

K., Takata, Y., Ogawa, H., Gomi, T., Fujioka, M., and Takusagawa, F. (2000) Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase crystal structures... 

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