Glycine-gated chloride channels

Inhibitory glycine receptor Strychnine-sensitive glycine receptor Glycine-gated chloride channel Glycine-gated anion channel... 

Kondratskaya, E. L. Lishko, P. V. Chatteijee, S. S. Krishtal, O. A. BN52021, aplatelet factor antagonist, is a selective blocker of glycine-gated chloride channel. Neurochem. Int., 2002, 40 647-653. 

Eroh M, Tliui man RG, Wheeler MD (2002) Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am J Physiol Gasd ointest Liver Physiol 283 G856-G863. 

Clinical concentrations of inhalational anesthetics enhance the capacity of glycine to activate glycine-gated chloride channels (glycine receptors), which play an important role in inhibitory neurotransmission in the spinal cord and brainstem. Propofol, neurosteroids, and barbiturates also potentiate glycine-activated currents etomidate and ketamine do not. Subanesthetic concentrations of the inhalational anesthetics inhibit some classes of neuronal nicotinic ACh receptors these actions do not appear to mediate anesthetic immobilization but could mediate other components of anesthesia such as analgesia or amnesia. 

Histamine-, Proton- and Glycine-gated Chloride Channels... 

Balansa W, Islam R, Gilbert DF, Fontaine F, Xiao X, Zhang H, et al. Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator. Bioorg Med Chem 2013 21(14) 4420-5. 

Langosch D, Becker CM, Betz H (1990) The inhibitory glycine receptor a ligand gated chloride channel of the central nervous system. Eur. J. Biochem., 194, 1-8. 

Cytoplasmic chloride must be transported outward to generate the gradient that allows GABA or glycine-gated channels to hyperpolarize neurons 87... 

Glycine receptors (Gly-Rs) are inhibitory, strychnine-sensitive, Gly-gated chloride (Cl-) channels with homology to other NT-gated ion channel receptors such as the nACh-Rs. On Gly binding, the Gly-gated chloride (Cl-) channel opens with consequent inhibitory hyperpolarization (i.e. the transmembrane potential (t] m) becomes more negative inside with respect to the outside) (Table 3.3). 

---