Glycan-protein interactions

Glycan-Glycan Interactions Glycan-Protein Interactions Glycopeptides and Glycoproteins, Synthesis of Isolation of Glycans... 

Glycan Binding Proteins (GBPs) and Glycan-Protein Interactions... 

Raman R, Sasisekharan R. Cooperativity in glycan-protein interactions. Chem. Biol. 2007 14 873-874. 

Figure 15 Synthetic compounds that modulate glycan-protein interactions, (a) Sialyl Lewis x and small molecule antagonists (b) multivalent selectin antagonists (c) Shiga toxin-like antagonist (d) cholera toxin and enterotoxin antagonists.

Glycans immobilized covalently are stable under various conditions. These glycochips have been used for investigating glycan-protein interactions, HTS and lectin/glycoenzyme discovery. 

The non-covalent interactions in many of natural compounds commonly referred as biomolecules are responsible for veiy important biological processes. The molecular recognition process in biological systems is observed between such species as receptor-ligand, antigen-antibody, sugar-lectin, DNA-protein, RNA-ribosome and others. The kinetics of the majority of glycan-protein interactions is fast and with dissociation... 

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