Glycan modification

The modification of molecules with saccharides also has the effect of increasing the hydrophilicity of the resultant complex due to the presence of multiple hydroxyl groups. Native glycan modification of proteins functions in much the same manner, because the carbohydrate... 

Similar results were recently obtained with a human monoclonal antibody, with KDEL sequences fused to the C-termini of both heavy chains, expressed in tobacco [33]. As observed for the invertase-HDEL fusion, about 90% of the N-linked glycans on this antibody were of the high-mannose type, with 6-9 mannose residues, while a fraction contained the immunogenic P(l,2)-xylose glyco-epitope (Fig. 15.6). However, this antibody was not a(l,3)-fucosylated, a glycan modification occurring in the trans Golgi [34]. 

Glycan modification of a foreign protein produced in a plant host using... 

Testicular angiotensin-converting enzyme with different glycan modification characterization on glycosylphosphatidylinositol-anchored protein releasing and dipeptidase activities (2009) Kondoh et al. [56]... 

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