Glyburide metformin combination

Patients previously treated with combination therapy of glyburide (or another sulfonylurea) plus metformin, if switched to glyburide/metformin hydrochloride, the starting dose should not exceed the daily dose of glyburide (or equivalent dose of another sulfonylurea) and metformin already being taken. 

Dailey GE III, Noor MA, Park J-S, Brace S, Fiedorek FT. Glycemic control with glyburide/metformin tablets in combination with rosiglitazone in patients with type 2 diabetes a randomised double-blind trial. Am J Med 2004 116 223-9. 

Fisman EZ, Tenenbaum A, Boyko V, Benderly M, Adler Y, Friedensohn A, Kohanovski M, Rotzak R, Schneider H, Behar S, Motro M. Oral antidiabetic treatment in patients with coronary disease time-related increased mortality on combined glyburide/metformin therapy over a 7.7-year follow-up Clin Cardiol 2001 24(2) 151-8. 

The client diagnosed with Type 2 diabetes is receiving the combination oral antidiabetic medication glyburide/metformin (Glucovance). Which data indicate the medication is effective ... 

Combination with metformin- Glyburide also may be used concomitantly with metformin when diet and glyburide or diet and metformin alone do not result in adequate glycemic control (see Metformin monograph). 

Two relatively new formulations of metformin are available. Glucovance is a combination of metformin and glyburide that may be helpful for diabetics who require both a sulfonylurea and metformin, and Glu-cophage XR is an extended-release product of metformin that may be better tolerated in some patients who are prone to gastrointestinal side effects. Metformin is usually given two to three times a day at mealtimes. 

---