Glyburide hypoglycaemia

Lin G, Hays DP, Spillane L. Refractory hypoglycaemia from ciprofloxacin and glyburide interaction. J Toxicol Clin Toxicol 2004 42 295-7. 

Roberge RJ, Kaplan R, Frank R, Fore C. Glyburide-cipro-floxacin interaction with resistant hypoglycaemia. Ann Emerg Med 2000 36 160-3. 

Leblanc M, Belanger C, Cossette P. Severe and resistant hypoglycaemia associated with concomitant gatifloxacin and glyburide therapy. Pharmacotherapy 2004 24 926-31. 

Data on relative safety suggest that chlorpropamide is the most toxic sulphonylurea (Ferner, 1988), but glyburide causes more dangerous hypoglycaemias than chlorpropamide. Glibenclamide has been shown to have a delayed effect on stimulating insulin secretion and this may be responsible for many unexpected severe hypoglycaemic episodes (Turner et al., 1987). 

An elderly diabetic woman taking glibenclamide (glyburide) and phenformin developed hypoglycaemia when given maprotiline. She was restabilised on half the dose of glibenclamide and phenformin. ... 

Isolated reports describe hypoglycaemia in two diabetic patients, one taking glipizide, the other taking glibenclamide (glyburide). The effects were attributed to the concurrent use of heparin. 

Scelleman H, Bilker WB, Bresinger CM, Wan F, Hennessy S. Anti-infectives and the risk of severe hypoglycaemia in users of glipizide and glyburide. Clin Pharmacol Ther 2010 88 214-22. 

Howard, F. M. (1975) Hypoglycaemia in Diabetics treated with Micronase (Glyburide). In Micronase. Pharmacological and Clinical Evaluation, p. 164. Editor H. Rifkin. Excerpta Medica, Amsterdam. 

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