Enzymes glutathione S-transferase

Soffers AEMF, Ploeman JHTM, Moonen MJH, Wobbes T, van Ommen B, Vervoort J, et al. Regioselectivity and quantitative structure-activity relationships for the conjugation of a series of fluoronitrobenzenes by purified glutathione S -transferase enzymes from rat and man. Chem Res Toxicol 1996 9 638-46. 

Hepatocellular changes at all dose levels, including histopathology and altered activities of glutathione S-transferase enzymes Acute oral LD50... 

Edwards, R., Dixon, D. P., and Walbot, V. 2000. Plant glutathione S-transferases enzymes with multiple functions in sickness and in health. Trends Plant Sci. 5,193-198... 

Glutathione S-transferase enzymes have been detected In a variety of different plant species (24,76.64.97.101.107-110). Howevei, detailed enzyme studies have been limited to corn (24.76, J09., 12 ) and pea (. JOT., 110). The foliar tissue of corn contains a GST Isozyme that appears rather unique In Its ability to catalyze the conjugation of various 2-chloro-s-trlazlnes with GSH (78). The molecular weight and other properties of this Isozyme are similar to those reported for many mammalian GST Isozymes however, the pH optimum of this Isozyme for atrazine Is somewhat lower than that reported for many GST Isozymes (, 78,J09.). When corn Is treated with R-25788, a second Isozyme Is Induced ( ). The Induced Isozyme Is very effective In catalyzing the GSH conjugation of an a-chloroacetamlde herbicide (alachlor), but It was not assayed with atrazine ( ). 

FIGURE 3.6 Human glutathione S-transferase enzymes. (Adapted from [58].)... 

K18. Kraus, P., and Gross, B., Particle-bound glutathione S-transferases. Enzyme 24, 205-208 (1979). 

Table 4. Substrates studies of glutathione S-transferase enzyme in the liver of Ictalurus melas exposed to mercury ...

Vervoort, P. J. van Bladeren, and I. M. C. M. Rietjens, Chem. Res. Toxicol., 9, 638 (1996). Regioselectivity and Quantitative Structure-Activity Relationships for the Conjugation of a Series of Fluoronitrobenzenes by Purified Glutathione S-Transferase Enzymes from Rat and Man. 

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