Glutathione oxidized, cleavage

Benzotrithiole. Y-oxide is capable of causing efficient DNA cleavage in the presence of 2-mercaptoethanol or glutathione and exhibited potent cytotoxicity against certain cancer cell lines <2002BML3259>. 

Figure 7. Cleavage of oxidized glutathione in seawater by tributylphosphine to yield reduced glutathione (red. Glut.) detection by fluorescence derlvatization and HPLC. Upper Oxidized glutathione (IpM) alone. Middle Oxidized glutathione (IpM) plus tributylphosphine (50 pl/lOOml seawater) reacted for 20 min at 25°C Lower Reduced glutathione standard (2pM) in seawater.

Figure 9. Identification of metabolites A through D in urine of rats treated with CDA led to the proposed hidden metabolites shown here in brackets. The reactive sulfate conjugate apparently undergoes glutathione conjugation, further metabolism via the mercapturic acid pathway and, finally, C-S cleavage, methylation and sulfur oxidation of C to yield D.

Thiophene derivatives are subject to S-oxidation followed by conjugation with glutathione however, other routes of metabolism, involving ring cleavage, are also possible. The resulting mercapturic acid derivative is eliminated in the urine (Dansette et al., 1992 Valadon et al., 1996). 

Anonaine AT m dissipation, increase of intracellular nitric oxide, ROS, glutathione depletion, caspase activation and PARP cleavage Human cervical cancer cell Hela Alkaloid isolated from plant M c/ze/ifl alba (Magnoliaceae) [129]... 

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