Glutathione-GST

All other metabolites are postulated intermediates GSH, glutathione GST, glutathione 5-transferase... 

Fig. 32.1 (a) The chemical structure of glutathione, (b) the structure of glutathione-GST dimer. The glutathiones were drawn as van der Walls sphere... 

The superscripts of each variable correspond to the name of a solute, monomer, or complex. Each energy term of the monomer and complex proteins are obtained from the independent MD simulations of glutathione, the GST dimer, and the glutathione-GST dimer in water. 

Conjugate herbicides containing an electrophilic site with glutathione (GST proteins). 

Figure 5 The integrated antioxidant defense system comprises both endogenous and dietary-derived antioxidants. GR, glutathione reductase (EC1.6.4.2) GSH, reduced glutathione GSH-Px, glutathione peroxidase (EC1.11.1.9) GSSG, oxidized glutathione GST, glutathione-S-transferase (EC 2.5.1.18) MSR, methionine sulfoxide reductase (EC1.8.4.5) NADPH and, NADP, are, respectively, the reduced and oxidized forms of the co-factor nicotinamide adenine dinucleotide phosphate PUFA, polyunsaturated fatty acid S-AA, sulfur amino-adds SH, sulfydryl SOD, superoxide dismutase (EC1.15.1.1).

The experiments were carried out with two enzymes, urease and glutathione-5-trans-ferase (GST). Urease catalyses the hydrolysis of urea (Avrameas 1978), while GST is an... 

Figure 7-12. Use of glutathione S-transferase (GST) fusion proteins to purify recombinant proteins. (GSH, glutathione.)...

The assessment of clearance is complicated by the numerous mechanisms by which compounds may be cleared from the body. These mechanisms include oxidative metabolism, most commonly by CYP enzymes, but also in some cases by other enzymes including but not limited to monoamine oxidases (MAO), flavin-containing monooxygenases (FMO), and aldehyde oxidase [45, 46], Non-oxidative metabolism such as conjugation or hydrolysis may be effected by enzymes such as glucuronyl transferases (UGT), glutathione transferases (GST), amidases, esterases, or ketone reductases, as well as other enzymes [47, 48], In addition to metabolic pathways, parent compound may be excreted directly via passive or active transport processes, most commonly into the urine or bile. 

The common mechanisms of drug resistance in ovarian cancer include (1) alteration of drug inactivation by agents such as glutathione-S-transferase (GST), (2) enhanced DNA repair,... 

The potential of coupling SPR with mass spectrometry has been demonstrated using glutathione-S-transferase (GST) and an anti-GST... 

---