Glutathione conjugates disposition

Disposition in the Body. Readily absorbed after oral administration, but subject to extensive first-pass metabolism. It is metabolised mainly in the liver by O-dealkylation to paracetamol and acetaldehyde, followed by conjugation of the paracetamol with sulphate or glucuronic acid (see under Paracetamol) other reactions are deacetylation to phenetidine (/7-ethoxyaniline), N-,2-, and a-hydroxylation forming mainly 2-hydroxyphenet-idine and also 2-hydroxyphenacetin, sulphate conjugation of de-acetylated metabolites, and glutathione conjugation to form... 

Chen, C., Hennig, G.E., and Manautou, J.E. (2003) Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR ) hyperbilirubinemic rats. Drug Metabolism and Disposition, 31 (6), 798-804. 

M Y Moridani, H Scobie, A Jamshidzadeh, P Salehi and P J O Brien, Cafifeic add, chlorogenic acid, and dihydrocaffeic acid metabolism Glutathione conjugate formation, Drug Metabolism and Disposition, 2001 29 1432-1439. 

S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene. Drug Metabolism and Disposition 19 703-707. 

Commanndeur JNM, Stintjes GJ, Vermeulen NPE (1995) Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Pharmacol Rev 47 271-330... 

The intracellular conjugation of xenobiotics with glutathione (GSH) results in their detoxication and adjusts their polarity to facilitate excretion from the cell (for recent reviews of GSH conjugation, see 1 and 2). Here the disposition of these GSH conjugates will be discussed. 

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