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Acetaminophen glutathione conjugation

Chen, C., Hennig, G.E., and Manautou, J.E. (2003) Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR ) hyperbilirubinemic rats. Drug Metabolism and Disposition, 31 (6), 798-804. [Pg.314]

Glutathione conjugation Glutathione (GSH) GSH-S-transferase (cytosol, microsomes) Epoxides, arene oxides, nitro groups, hydroxylamines Acetaminophen, ethacrynic acid, bromobenzene... [Pg.85]

Figure 5. Acetaminophen overdose induces liver necrosis by formation of more hepatotoxin (metabolite A) than can be deactivated by glutathione conjugation (metabolite B). ... Figure 5. Acetaminophen overdose induces liver necrosis by formation of more hepatotoxin (metabolite A) than can be deactivated by glutathione conjugation (metabolite B). ...
C. M-acetyl benzoquinoneimine is toxic, whereas acetaminophen glu-curonide, acetaminophen sulfate, and acetaminophen glutathionate are nontoxic acetaminophen conjugates. A -acetyl-p-aminophenol is another name for acetaminophen. [Pg.373]

Glutathione conjugation Ethacrynic acid, reactive Phase I metabolite of acetaminophen... [Pg.34]

Glutathione conjugation also occurs in the metabolism of acetaminophen (Tylenol ). Metabolic oxidation produces an N-acetylimidoquinone intermediate, which is highly reactive. [Pg.1069]

See other pages where Acetaminophen glutathione conjugation is mentioned: [Pg.393]    [Pg.380]    [Pg.229]    [Pg.393]    [Pg.380]    [Pg.229]    [Pg.138]    [Pg.198]    [Pg.81]    [Pg.424]    [Pg.394]    [Pg.1019]    [Pg.1257]    [Pg.1487]    [Pg.8]    [Pg.20]    [Pg.288]    [Pg.302]    [Pg.246]    [Pg.250]    [Pg.252]    [Pg.371]    [Pg.13]    [Pg.256]    [Pg.169]    [Pg.187]    [Pg.36]    [Pg.484]    [Pg.169]    [Pg.543]    [Pg.39]    [Pg.224]    [Pg.230]    [Pg.231]    [Pg.232]    [Pg.232]    [Pg.232]    [Pg.61]    [Pg.82]    [Pg.355]    [Pg.256]    [Pg.247]    [Pg.240]    [Pg.362]    [Pg.757]    [Pg.58]    [Pg.314]   
See also in sourсe #XX -- [ Pg.305 ]



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