Glutaric acid kinetics

C. Larsen, P. Kurtzhals, M. Johansen, Kinetics of Regeneration of Metronidazole from Hemiesters of Maleic Acid, Succinic Acid and Glutaric Acid in Aqueous Buffer, Human Plasma and Pig Liver Homogenate , Int. J. Pharm. 1988, 41, 121 - 129. 

The oxidation of ketones with chromic acid proceeds through enol intermediates, as proven by kinetic measurements [1175], 2-Chlorocyclo-hexanone is oxidized predominantly to adipic acid, with 2-chloroadipic acid, glutaric acid, and succinic acid as byproducts (equation 436) [1175]. 

The large excess of methanol was taken in this study due to the low solubility of glutaric acid in methanol. The kinetic data which had been determined experimentally for the esterification were correlated with quasi-homogeneous (QH) model (Schmitt Hasse, 2006). Comparing with the experimental values, the QH model represents well the conversions of glutaric acid and the mole fractions of each constituent component varying with the contact time. The values of the rate constants were determined by fitting the kinetic data to the reaction rate expressions simultaneously. The temperature dependent fei, k2, fe, ki were listed in Table 3,... 

The effect of a small amount of solvent on cocrystal formation has been investigated by Shan, Toda, and Jones. It was shown that the solvent does not only affect the kinetics but also the polymorphic outcome when caffeine and glutaric acid are ground together in the absence of... 

The synthesis in Scheme 13.26 is based on an interesting kinetic differentiation in the reactivity of two centers which are structurally identical but are diastereomeric. A bis-amide of meso-2,4-dimethylglutaric acid and a homochiral thiazoline is formed in step A. The thiazoline is derived from the amino acid cysteine. The two amide carbonyls in this bis-amide are nonequivalent by virtue of the diastereomeric relationship established by the chiral centers at C-2 and C-4 in the glutaric acid portion of... 

In 2011, Tsai, et al. investigated the kinetic behavior of heterogeneous esterification of dibasic acids such as glutaric add with methanol over Amberlyst 35. As shown in Equation (42) and Equation (43), the esterification includes two reversible reactions in series accompanying with an intermediate of monomethyl glutarate (MMG) ... 

Figure 3 shows the results of CALB-catalyzed polymerizations as a function of diacid chain length in solvent. The more rapid polymerization in diphenyl ether of sebacic (Cio) acid relative to shorter diacid substrates was evident by 4 and 8 h. However, by 24 and 48 h, the DPavg for sebacic and adipic diacid (Q) polymerizations was statistically equivalent. Similarly, polymerizations of succinic (C4) and glutaric (C5) diacids proceeded at similar rates. Thus, by 24 h, the relative extent of chain-build up for polymerizations with octane-1,8-diol in diphenyl ether was sebacic adipic > glutaric succinic acids. It may be that the kinetics of sebacic acid /1,8-octanediol polymerization is more rapid than for the other diacids studied. 

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