Glutamic-oxalacetic acid transaminase

SGOT Senna glutamic oxalacetic acid transaminase... 

Changes in glucose-6-phosphatase, forminoglutamic acid transferase, urocanase, formylase, methyl-H4-folate dehydrogenase, histidiase, glutamic oxalacetic transaminase and carbonyl transferase and ornithine... 

Urinary excretions of nicotinic acid metabolites and 2-pyridone, as well as of 4-pyridoxic and xanthurenic acids were determined in 15 South African Bantu pellagrins before and after tryptophan administration (P13). Red blood cell riboflavine levels and serum glutamic-oxalacetic transaminase levels were also measured. The authors discussed the apparent inability of the pellagra patients to convert tryptophan to nicotinic acid as indicated by their low excretion of nicotinic acid metabolites before and after tryptophan load. The possibility that the subjects were also suffering from a riboflavine deficiency was also discussed. 

Injection of hydrocortisone into the rat results in an approximately four fold increase in liver (but not kidney) tyrosine-a-ketoglutarate transaminase activity 374)- Corticosterone and cortisone were somewhat less effective. Interesting in this connection is the observation that injection of L-tyrosine increased the activity of tyrosine-a-ketoglutarate transaminase to about the same extent as hydrocortisone. Other amino acids had a much smaller stimulating effect which was attributed to adrenal cortical stress. In a preliminary report the addition of hydrocortisone to lymphocyte suspensions was found to inhibit glutamic-oxalacetic transaminase activity 376). 

Ti-Aspartic Oxidase. Aspartase and transaminases account for a major part of the metabolism of L-aspartic acid. n-Aspartic acid is oxidized by an enzyme present in liver and kidney. This is an oxidase that converts aspartate to oxalacetate and ammonia while reducing oxygen to hydrogen peroxide. The oxidase was resolved by ammonium sulfate precipitation and dialysis to a protein that could be reactivated by FAD but not by FMN. The enzyme differs from n-amino acid oxidase in its insensitivity to benzoate. The only other known substrate for the partially purified D-aspartic oxidase is D-glutamate, but since the relative rates of oxidation of the two amino acids vary during the preparation of the enzyme, it is... 

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