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Glutamatergic excitotoxicity

Hare, W. A., and Wheeler, L. (2009). Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells Block by memantine. Invest. Ophthalmol. Vis. Sci. First published on January 10, 2009 as doi 10.1167 /iovs.08-2103-... [Pg.420]

Glutamate is a major excitatory neurotransmitter in the central nervous system. Theoretically, increased glutamater-gic neuro transmission may lead to excitatory neurotoxicity or exci to toxicity. The only two currently approved neuroprotective agents in the United States, riluzole for ALS and memantine for AD, may act to prevent glutamatergic excitotoxicity. [Pg.568]

Excitotoxicity is the over-activity of the glutamatergic system responsible for the large number of dead neurons observed after ischemia (stroke) or epileptic seizures. This neuronal death is due to an overexcitation of the neurons and the massive Ca2+ entry... [Pg.487]

Memantine (Namenda) blocks glutamatergic neurotransmission by antagonizing N-methyl-D-aspartate receptors, which may prevent excitotoxic reactions. It is used as monotherapy, and data suggest that when it is combined with a cholinesterase inhibitor, there is improvement in cognition and activities of daily living. [Pg.744]

Danysz W, Parsons CG, Mobius HJ, et al (2000) Neuroprotective and symptomatological action of memantine relevant for Alzheimer s disease—an unified glutamatergic hypothesis on the mechanism of action. Neurotox Res 2 85-97 Davis SM, Lees KR, Albers GW, et al (2000) Selfotel in acute ischemic stroke possible neurotoxic effects of an NMDA antagonist. Stroke 31 347-354 DeKeyser J (1991) Excitotoxic mechanisms may be involved in the pathophysiology of tardive dyskinesia. Clin Neuropharmacol 14 562-565 Del Dotto P, Pavese N, Gambaccini G, et al (2001) Intravenous amantadine improves levodopa-induced dyskinesias an acute double-blind placebo-controlled study. Mov Disord 16 515-520... [Pg.288]

Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 2002 26(4) 438 158. [Pg.289]

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See also in sourсe #XX -- [ Pg.515 ]



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