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Glutamate transporters concentration

Excitotoxicity (see Chs 15 and 32) has been suggested to be a mechanism by which motor neurons are damaged in ALS [25,48,49]. About 60-70% of sporadic ALS patients have a 30-95% reduction in the levels of the astroglial glutamate transporter EAAT2 (excitatory amino acid transporter 2), also termed GLT-1, in motor cortex and spinal cord [25, 48, 49]. Reduction in level of activity of this major glutamate transporter leads to increased extracellular concentrations of glutamate at synapses and evidence of excitotoxicity exists in some patients with ALS. [Pg.732]

Dehnes, Y., Chaudhry, F. A., Ullensvang, K., Lehre, K. P, Storm-Mathisen, J., and Danbolt, N. C. (1998) The glutamate transporter EAAT4 in rat cerebellar Purkinje cells a glutamategated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia. J. Neurosci. 18, 3606-3619. [Pg.173]

See other pages where Glutamate transporters concentration is mentioned: [Pg.376]    [Pg.86]    [Pg.87]    [Pg.271]    [Pg.287]    [Pg.560]    [Pg.597]    [Pg.881]    [Pg.147]    [Pg.161]    [Pg.162]    [Pg.166]    [Pg.168]    [Pg.169]    [Pg.170]    [Pg.196]    [Pg.272]    [Pg.508]    [Pg.461]    [Pg.462]    [Pg.537]    [Pg.375]    [Pg.8]    [Pg.9]    [Pg.51]    [Pg.51]    [Pg.52]    [Pg.56]    [Pg.56]    [Pg.60]    [Pg.63]    [Pg.64]    [Pg.64]    [Pg.75]    [Pg.113]    [Pg.161]    [Pg.263]    [Pg.121]    [Pg.82]    [Pg.92]    [Pg.94]    [Pg.95]    [Pg.96]    [Pg.302]    [Pg.304]    [Pg.311]    [Pg.311]    [Pg.42]    [Pg.747]   
See also in sourсe #XX -- [ Pg.236 , Pg.237 , Pg.240 , Pg.244 ]



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