Glutamate kinase

This enzyme [EC 2.7.2.11], also known as glutamate 5-kinase, catalyzes the reaction of ATP with L-glutamate to produce ADP and L-glutamate 5-phosphate, which is rapidly converted in aqueous solutions to 5-oxoproline and orthophosphate. 

Marina, A. Uriarte, M. Barcelona, B. Fresquet, V Cervera, J. Rubio, V. Carbamate kinase from Enterococcus faecalis and Enterococcus faecium-cloning of the genes, studies on the enzyme expressed in Escherichia coli, and sequence similarity with N-acetyl-L-glutamate kinase. Eur. J. Biochem., 253, 280-291 (1998)... 

Gil-Ortiz, E Ramon-Maiques, S. Fita, L Rubio, V. The course of phosphorus in the reaction of N-acetyl-L-glutamate kinase, determined from the structures of crystalline complexes, including a complex with an AlF(4)(-) transition state mimic. J. Mol. Biol., 331, 231-244 (2003)... 

Vasakova, L. Stefl, M. Glutamate kinases from winter-wheat leaves and some properties of the proline-inhibitable glutamate kinase. Collect. Czech. Chem. Commun., 47, 349-359 (1982)... 

Transduction mechanism Inhibition of adenylyl cyclase stimulation of tyrosine phosphatase activity stimulation of MAP kinase activity activation of ERK inhibition of Ca2+ channel activation stimulation of Na+/H+ exchanger stimulation of AM PA/kainate glutamate channels Inhibition of forskol in-stimulated adenylyl cyclase activation of phos-phoinositide metabolism stimulation of tyrosine phosphatase activity inhibition of Ca2+ channel activation activation of K+ channel inhibition of AM PA/ kainate glutamate channels inhibition of MAP kinase activity inhibition of ERK stimulation of SHP-1 and SHP-2 Inhibition of adenylyl cyclase stimulation of phosphoinositide metabolism stimulation of tyrosine phosphatase activation of K+ channel inhibi-tion/stimulation of MAP kinase activity induction of p53 and Bax Inhibition of adenylyl cyclase stimulation of MAP kinase stimulation of p38 activation of tyrosine phosphatase stimulation of K+ channels and phospholipase A2 Inhibition of adenylyl cyclase activation/ inhibition of phosphoinositide metabolism inhibition of Ca2+ influx activation of K+ channels inhibition of MAP kinase stimulation of tyrosine phosphatase... 

Chen L, Huang LY Sustained potentiation of NMD A receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid. Neuron 7 319-326, 1991... 

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