Glutamate in epilepsy

Ikonomidou and Turski, 2002 Yi and Hazell, 2006). This suggests a cocktail of glutamate receptor antagonists, glutamate transporter inhibitors, antioxidants, and anti-inflammatory drugs may have beneficial effects in traumatic head injury. 

Epileptic seizures also stimulate CPLA2 activity and expression with accumulation of arachidonic acid (Visioli et al., 1994 Kajiwara et al., 1996). Levels of free fatty acids and diacylglycerols in rat brain rise rapidly with the onset of epileptic 

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The action of glutamate in epilepsy is assumed to be the consequence of NMDA-receptor binding and of AMPA-receptor activation as well. In vivo kindling studies provoke epileptic activity. In vitro application of glutamate on hippocampal cell cultures burst firing. These phenomena can be reduced by NMDA antagonists. 

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