Glucuronosyltransferases, intestinal

Czernik, P.J., Little, J.M., Barone, G.W., Raufman, J.P., and Radominska-Pandya, A. (2000) Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Drug Metab Dispos 28 1210— 1216. 

Wen Z, Tallman MN, Ali SY, et al. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes structural characterization of phenolic and alcoholic glu-curonides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos 2007 35(3) 371-380. 

Radominska-Pandya A, Little J, Pandya J, et al. UDP-glucuronosyltransferases in human intestinal mucosa. Biochimica et Biophysica Acta 1998 1394 199-208. 

Strassburg CP, Kneip S, Topp J, et al. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 2000 275(46) 36164-36171. 

Cheng Z, Radominska-Pandya A, Tephly TR. Studies on the substrate specificity of human intestinal UDP-glucuronosyltransferases 1A8 and 1A10 [in process citation]. Drug Metab Dispos 1999 27(10) 1165-1170. 

In about 90% of all neonates, jaundice occurs after the first 2-5 days of life and rarely exceeds 6 mg/dl serum bilirubin. In premature infants, bilirubin levels can rise to 10-12 mg/dl. The cause is related to a number of factors .) reinforced degradation of haemoglobin as a result of the short erythrocyte survival span of 70-90 days (120 days in adults), (2.) reduction in cellular transport proteins, above all ligandin, (i.) deficiency of uri-dyltransferase and glucuronosyltransferase, and (4.) increasing intestinal absorption of meconium bilirubin. 

Zhang, L., Lin, G. and Zuo, Z. (2007) Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein. Pharmaceutical Research, 24, 81-89. 

LOEL 250 mg/kg/day (mice) 125 mg/kg/day [10, 11] (rats) hepatocellular hypertrophy NOEL 10 mg/kg/day increases in liver and [1] kidney weights, increases in the incidence of hepatocellular hypertrophy, increases in thyroidparathyroid weights, hypertrophy and hyperplasia of the thyroid high incidences of trace-to-mild chronic nephritis in kidneys of male rats and increased pigmentation of the renal tubules in female rats LOAEL = 312 mg/kg/day (rats) 125 mg/kg/day [10, 11] (mice) hepatocellular neoplasms and adenomas or adenocarcinomas of the liver mononuclear cell leukemia adenomas or hyperplasia of the renal tubular cells in exposed male rats follicular cell adenomas or carcinomas of the thyroid in exposed female rats and female mice alveolar/bronchiolar adenomas or carcinomas in male mice 52 mg/kg Paroil intestinal activities of aryl [13] hydrocarbon hydroxylase (increase), UDP-glucuronosyltransferase (decrease) and epoxide hydrolase (increased)... 

Van der Logt, E.M., Roelofs, H.M., Nagengast, F.M., and Peters, W.H., Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. Carcinogenesis, 2003. 

Studies on the Substrate Specificity of Human Intestinal UDP-Glucuronosyltransferases 1A8 and lAlO. 

---