Glucuronides of thyroxine

While this pattern of biochemistry does not exclude transient relapse of Graves hyperthyroidism (despite the finding of negative TSH receptor antibodies), or a transient thyroiditis, the authors speculated that indinavir (prescribed in this patient together with stavudine and lamivudine) had inhibited the glucuronidation of thyroxine and hence caused a rise in serum thyroid hormone concentrations. 

Finnson, K.W. and J.G. Eales. Glucuronidation of thyroxine and 3,5,3 -triiodothyronine by hepatic microsomes in rainbow trout, Oncorhynchus mykiss. Comp. Biochem. Physiol. 120C 415-420, 1997. 

Tong, Z., Li, H., Goljer, I., McConnell, O., and Chandrasekaran, A. (2007) In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases. Drug Metab. Dispos. 35, 2203-2210. 

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See also in sourсe #XX -- [ ]

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