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Glucuronide linkage

Specimen preparation for cannabinoid testing frequently includes a hydrolysis step to free cannabinoids from their glucuronide conjugates. Most GC/MS confirmation procedures in urine measure total THCCOOH following either an enzymatic hydrolysis with //-glucuronidase, or more commonly, an alkaline hydrolysis with sodium hydroxide. Alkaline hydrolysis appears to efficiently hydrolyze the ester THCCOOH glucuronide linkage. [Pg.670]

Details of the selective cleavage of o-glucuronidic linkages in saponins have been published (see Vol. 10, p. 117). A modified procedure for determining the sites of attachment of hexuronic acid residues in methylated acidic polysaccharides by base-catalysed degradation has been modelled on experiments with the methylated aldobiouronic acid derivative (430), which eliminated methyl 2,3,4-tri-O-methyl-p-D-glucopyranoside (89%) on treatment with sodium methylsulphinyl-methanide in DMSO at room temperature. When this procedure is applied to... [Pg.137]

A new method for selectively cleaving the D-glucuronidic linkages of saponins is based on oxidative decarboxylation of per-C>-methylated derivatives with lead tetra-acetate in benzene, followed by release of the aglycone with base (Scheme... [Pg.117]

Thus, the results of degradation studies have established the P-(i - -3)-glucuronidic linkage, and suggested a linkage at C-4 of the glucuronic moiety. [Pg.279]

Animals. 98.5-100% of 14C was excreted within 7 days. The major metabolic routes were deethylation of the 4-ethoxy group, cleavage of the carbamate linkage, acetylation, and finally formation of the glucuronide and sulfate conjugates... [Pg.1932]


See other pages where Glucuronide linkage is mentioned: [Pg.258]    [Pg.233]    [Pg.521]    [Pg.258]    [Pg.670]    [Pg.85]    [Pg.220]    [Pg.200]    [Pg.200]    [Pg.279]    [Pg.708]    [Pg.258]    [Pg.233]    [Pg.521]    [Pg.258]    [Pg.670]    [Pg.85]    [Pg.220]    [Pg.200]    [Pg.200]    [Pg.279]    [Pg.708]    [Pg.96]    [Pg.226]    [Pg.126]    [Pg.354]    [Pg.130]    [Pg.128]    [Pg.459]    [Pg.498]    [Pg.958]    [Pg.856]    [Pg.1252]    [Pg.139]    [Pg.272]    [Pg.90]    [Pg.98]    [Pg.104]    [Pg.82]    [Pg.187]    [Pg.120]    [Pg.66]    [Pg.80]    [Pg.159]    [Pg.118]    [Pg.536]    [Pg.63]   
See also in sourсe #XX -- [ Pg.7 , Pg.156 , Pg.157 ]

See also in sourсe #XX -- [ Pg.7 , Pg.156 , Pg.157 ]




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Glucuronidated

Glucuronidation

Glucuronides

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