Glucuronide formation and

Metabolism of the A -amino group is usually the more important and this group can undergo three reactions, namely A -acetylation, A -glucuronide formation, and A -sulfate synthesis (126). 

Ki etz-Rommel, A. Boelsterli, U.A. "Diclofenac Covalent Protein Binding is Dependent on Acyl Glucuronide Formation and is Inversely Related to P450-mediated Acute Cell Injury in Cultured Rat Hepatocytes," Toxicol. Appl. Pharmacol. 120(1), 155-161 (1993). 

A study in 24 EHV-positive patients found that alcohol 0.7 g/kg increased the AUC of a single 600-mg dose of abacavir by 41%. The half-life of abacavir was increased by 26%, from 1.42 to 1.79 hours. The pharmacokinetics of alcohol were not affected by abacavir. Alcohol may inhibit the formation of abacavir carboxylate resulting in a trend towards increased abacavir glucuronide formation and reduced abacavir metabolism. The increase in exposure to abacavir was not considered to be clinically significant, since it is within levels seen in other studies using higher doses, which demonstrated no additional safety concerns at doses of up to three times the recommended daily dose of abacavir. No special precautions therefore appear to be necessary. 

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