Glucuronidase tumor-activated prodrugs

In contrast, using enzyme histochemical methods, it was observed that lysosomal (3-glucuronidase was liberated in necrotic tumor areas as functionally active enzyme (75). The cells responsible for the liberation of the enzyme are mainly acute and chronic inflammatory cells, as shown by immunochemistry (74). These observations led to the development of the new concept of prodrug monotherapy (PMT) (74, 75). 

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