Glucuronic acid pathway

Glucose-6-phosphate transporter in hepatocyte microsomal membrane Phosphate transporter in hepatocyte microsomal membrane 

III Forbes disease, Cori s disease (limit dextrinosis) 

CHAPTER 15 Carbohydrate Metabolism II Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways 

Lactic acidosis and substrate cycling in glucose-6-phosphatase deficiency. Urinary lactate output is increased 10- to 300-fold in patients with type I glycogen storage disease. 

Glucuronic acid pathway. The first part consists of synthesis of UDP-glucuronic acid and release of free D-glucuronic acid. The second part is the metabolism of D-glucuronic acid. D-Glucuronic acid is written as both the cyclic hemiacetal and the open-chain aldohexose and two orientations of L-gulonic acid and D-xylulose are shown. P = phosphate. 

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Figure 7.57 The metabolism of aspirin (acetylsalicylic acid). Step 1 (hydrolysis) yields the major metabolite, salicyclic acid, which is conjugated with glucuronic acid (pathways 2 and 4) or glycine (pathway 3). All these three pathways (2, 3, and 4) are saturable.

This is a harmless inborn error caused by a deficiency of l-xylulose reductase, an enzyme involved in the glucuronic acid pathway. 

The glucuronic acid pathway (Figure 15-15) is a quantitatively minor route of glucose metabolism. Like the pentose phosphate pathway, it provides biosynthetic precursors and interconverts some less common sugars to ones that can be metabolized. 

IMagram of the glucuronic acid pathway ot glucose metabolism. 

FIGURE 1. The biosynthetic pathway of ascorbic acid with relationship to the D-glucuronic acid pathway. X is a conjugating molecule for glucuronidation. 

Figure 6. Scheme of the metabolic activities and Glucuronic Acid Pathway of... 

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