Glucosiduronic estriol

Methytation of alcohols. Although alcohols alone are inert to diazomethane, they can be methylated efficiently by diazomethane under catalysis by boron trifluoride etherate or fluoroboric acid. A mineral acid cannot be used for catalysis because it itself reacts with the reagent, but a Lewis acid performs the function ascribed above to an organic acid. In investigating the structure of estriol D-glucosiduronic acid,... 

Estriol glucosiduronate appears to be selectively retained in the amniotic fluid, probably because glucosiduronates are poorly transferred... 

Hashimoto and Neeman (1963) have obtained pure crystalline estriol 16a-glucosiduronic acid from third trimester human pregnancy urine, completely characterized it and converted it to two derivatives. Infrared spectroscopy was used in the identification of these compounds, methyl(3,17/S-dimethoxyestra-l,3,5(10)-trien-16a-yl-2, 3, 4 -tri-0-methyl-)S-D-glucopyranosid) uronate, and methyl (3-methoxy-17/S-acetoxyestra-l,3,5(10)-trien-16a-yl-2, 3, 4 -tri-O-acetyl-)5-D-glucopyranosid)-uronate. 

The 100,000 g supernatant from guinea pig liver homogenate was used by IjCvitK et al. (1005) to biosynthesize estriol-3-suIfo-16-gluc< iduronate from the glucosiduronate in the presence of jVTP and magnesium sulfate. 

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